| Act |
| Johns Hopkins Colon Cancer Genetic Testing Study |
 |
|
This clinical trial is listed at the request of the researchers who are running the study. Genetic Health does not specifically endorse this study and does not receive compensation for listing it. Before you participate in any clinical trial, you should carefully review the trial's informed consent document so you are aware of the risks and benefits of participation.
|
|
|
What Is This Study About?
|
Hereditary Nonpolyposis Colorectal Cancer (HNPCC) is an inherited syndrome that includes colon cancer and other cancers and is caused by a mutation in a gene. There is a genetic test that can tell some people if they are likely to have the gene mutation for HNPCC. The genetic test is only good for people with a strong family history of colorectal cancer. Little is known about the benefits of taking gene tests. In order to learn more about the risks and benefits of genetic testing, we offer the free and confidential genetic testing as part of a research study. The study is divided into Phases I and II.
|
|
 top
|
| Who Is Doing the Research? |
The research team includes a clinical psychologist, a research nurse, a genetic counselor, a geneticist, and study coordinators.
|
|
top
|
Who Is Eligible to Participate in Phase I?
|
|
To be in Phase I a person must:
- Be 18 years of age or older.
- Have one parent, sibling, or child who was diagnosed with colon cancer at 50 years of age or younger and is willing to donate a blood sample.
- Come to Johns Hopkins once, along with a relative or friend.
Phase I is intended to study the participant's knowledge and attitudes toward colon cancer and gene testing. Participants will fill out questionnaires about their moods, attitudes, and health care practices.
|
|
top
|
| Who Is Eligible to Participate in Phase II? |
To be in Phase II a person must:
- Complete Phase I.
- Have a living relative who currently has or has had colon cancer and who will give a blood sample for genetic testing.
- If your relative is found to have a colon cancer gene mutation, give your own blood sample for genetic testing.
- Complete interviews and questionnaires five or six more times.
Phase II is intended to study how learning genetic information about yourself or your relative affects your health care decisions and general well being.
|
|
top
|
Contact Information
|
|
If you want more information or would like to participate in this study, please contact:
Miriam Tillery
Research Coordinator
Colon Cancer Genetic Testing Study
Johns Hopkins Hospital
600 North Wolfe Street Meyer 218
Baltimore, MD 21287-7218
Telelphone: (410) 502-5405
E-mail: mtillery@jhmi.edu
|
|
top
|
Background Information
|
|
HNPCC can be caused by mutations in one of several genes. People who have a strong family history of colon cancer are more likely to carry one of these mutations — and therefore be at increased risk of colon cancer — than are people in the general population. Using a blood test, it is now possible to determine if a healthy person in such a family has one of these gene mutations. If we find such a mutation, we offer specific recommendations for preventing colon cancer or detecting it in an early stage. Our long-range goal is to provide genetic information in a way that increases a person's willingness to be screened for colon cancer.
|
| <<Previous
Article |
Main
Topic Page
|
Next
Article>>
|
|
|
|
|
Untitled Document
©Copyright 2000, 2001 Genetic Health. All Rights Reserved.
Contact Us |
|
